Selected Recent Publications

Almeida AR, Macklin WB. Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate. Elife. 2023 Apr 20;12:e82111. doi: 10.7554/eLife.82111. PMID: 37078701; PMCID: PMC10198724. 

Dahl KD, Almeida AR, Hathaway HA, Bourne J, Brown TL, Finseth LT, Wood TL, Macklin WB. mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System. J Neurosci. 2023 Jan 25;43(4):540-558. doi: 10.1523/JNEUROSCI.0010-22.2022. Epub 2022 Dec 2. PMID: 36460463; PMCID: PMC9888514. 

Adams KL, Dahl KD, Gallo V, Macklin WB. Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation. Semin Cell Dev Biol. 2021 Aug;116:16-24. doi: 10.1016/j.semcdb.2020.10.002. Epub 2020 Oct 22. PMID: 34110985; PMCID: PMC9302595. 

Brown TL, Hashimoto H, Finseth LT, Wood TL, Macklin WB. PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination. J Neurosci. 2021 Mar 3;41(9):1864-1877. doi: 10.1523/JNEUROSCI.0229-20.2021. Epub 2021 Jan 21. PMID: 33478987; PMCID: PMC7939082. 

Brown TL, Macklin WB. The Actin Cytoskeleton in Myelinating Cells. Neurochem Res. 2020 Mar;45(3):684-693. doi: 10.1007/s11064-019-02753-0. Epub 2019 Mar 7. PMID: 30847860; PMCID: PMC6732044. 

Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. doi: 10.1016/j.expneurol.2019.04.011. Epub 2019 Apr 25. PMID: 31029597; PMCID: PMC6615458. 

Preston MA, Finseth LT, Bourne JN, Macklin WB. A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination. Glia. 2019 Apr;67(4):650-667. doi: 10.1002/glia.23559. Epub 2019 Jan 9. PMID: 30623975; PMCID: PMC6555554. 

Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL. Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica. Glia. 2018 Dec;66(12):2575-2588. doi: 10.1002/glia.23512. Epub 2018 Sep 21. PMID: 30240044; PMCID: PMC6309481. 

Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB. Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife. 2018 Feb 13;7:e34783. doi: 10.7554/eLife.34783. PMID: 29436368; PMCID: PMC5828668. 

Ahrendsen JT, Harlow DE, Finseth LT, Bourne JN, Hickey SP, Gould EA, Culp CM, Macklin WB. The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination. J Neurosci. 2018 Jan 24;38(4):787-802. doi: 10.1523/JNEUROSCI.2864-16.2017. Epub 2017 Dec 7. PMID: 29217681; PMCID: PMC5783963. 

Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 Mar 24;5(1):25. doi: 10.1186/s40478-017-0428-6. PMID: 28340598; PMCID: PMC5366134. 

Hussain R, Macklin WB. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017 Jan 11;37(2):397-412. doi: 10.1523/JNEUROSCI.2113-16.2016. PMID: 28077718; PMCID: PMC5242396. 

Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 Dec 1;13(1):301. doi: 10.1186/s12974-016-0767-4. PMID: 27905992; PMCID: PMC5134246. 

Verden D, Macklin WB. Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations. J Neurosci Res. 2016 Dec;94(12):1411-1420. doi: 10.1002/jnr.23923. Epub 2016 Sep 12. PMID: 27618492; PMCID: PMC9302593. 

Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB. Juvenile striatal white matter is resistant to ischemia-induced damage. Glia. 2016 Nov;64(11):1972-86. doi: 10.1002/glia.23036. Epub 2016 Jul 27. PMID: 27463063; PMCID: PMC5886370.